Trehalose 100PH (for Oral Dosage)

Trehalose 100PH is a highly purified, pharmaceutical-grade trehalose produced in Japan. This non-reducing disaccharide consists of two glucose molecules linked by an α,α–1,1 glycosidic bond. It appears as a white dihydrous crystalline powder, is highly soluble in water, and exhibits exceptional stability under heat and acidic conditions.

Trehalose’s non-reducing nature prevents caramelization and Maillard reactions during processing or heat sterilization. Its low hygroscopicity ensures free-flowing properties even under high relative humidity, while its high glass-transition temperature (~120 °C) allows it to maintain a stable glassy state at elevated temperatures.

With 38 % of the sweetness of a 5 % sucrose solution and minimal aftertaste, Trehalose 100PH offers a clean taste profile, making it ideal for oral solutions, chewable tablets, and other patient-friendly dosage forms.

NAGASE supplies Trehalose 100PH globally for pharmaceutical and nutraceutical applications, supported by technical expertise and international logistics.

Trehalose 100PH is used as a functional excipient in a variety of pharmaceutical and nutraceutical dosage forms.

• Additive for oral solutions – Acts as stabilizer, taste masker, and solubility enhancer for minerals
• Excipient for solid oral dosage forms – Improves stability and processability
• Chewable tablets and lozenges – Clean taste with reduced aftertaste
• Heat- and acid-stable excipient – Suitable for sterilization processes
• Nutraceutical formulations requiring stable, low-hygroscopicity ingredients

Trehalose 100PH offers stability, processability, and sensory advantages for sensitive pharmaceutical products.

• Clean taste profile – 38 % as sweet as 5 % sucrose, with reduced aftertaste
• Non-reducing sugar – No caramelization or Maillard reaction during heat processing
• Exceptional stability – Tolerates pH 2 at 100 °C for 24 hours
• Low hygroscopicity – Remains free-flowing under high humidity
• High glass-transition temperature – ~120 °C for stable glassy state at elevated temperatures

What is Trehalose 100PH?
Trehalose 100PH is a high-purity, low-hygroscopicity pharmaceutical-grade trehalose produced in Japan.

What are the main uses of Trehalose 100PH?
It is used as a stabilizer, taste masker, and solubility enhancer in oral solutions, and as an excipient in solid oral dosage forms.

Why is Trehalose 100PH suitable for heat processing?
Its non-reducing nature prevents caramelization and Maillard reactions, while its stability allows tolerance to pH 2 at 100 °C for 24 hours.

What makes Trehalose 100PH different from other sugars?
It offers a clean taste with less aftertaste, low hygroscopicity, and a high glass-transition temperature for improved stability.

Can NAGASE supply Trehalose 100PH globally?
Yes. NAGASE provides worldwide supply, technical support, and logistics for Trehalose 100PH.