MPC-Polymer for Eye Care

Biocompatible polymer for advanced ophthalmic and eye drop applications.
Improves tear film stability, relieves dry eye symptoms, and enhances comfort in contact lens wearers.

Phosphoryl Choline-Based Polymer for Dry Eye Relief and Ocular Health

MPC Polymer (2-Methacryloyloxyethyl Phosphoryl Choline) is a highly biocompatible polymer designed for ophthalmic applications. Its unique structure combines phosphoryl choline groups, which are strongly hydrophilic and suppress protein and cell adhesion, with methacrylic groups, which provide flexibility and versatility in formulations.

Already used as an additive in commercial eye drop solutions, MPC Polymer reduces discomfort caused by blurred vision due to excessive eye mucus. It improves ocular moisture retention, stabilizes the tear film, and supports cell protection against preservative-induced damage.

NAGASE supplies MPC Polymer globally for advanced ophthalmic formulations, eye drops, and contact lens care products, with full technical expertise and international distribution support.

Applications

MPC Polymer is widely applied in ophthalmic formulations for improved ocular comfort and dry eye management.

  • Additive in eye drop solutions to reduce blurred vision
  • Dry eye treatment with improved tear film stability
  • Ocular surface protection against preservatives
  • Moisturizing agent in ophthalmic formulations
  • Compatible with hard and soft contact lens care

Features

MPC Polymer delivers moisturizing, protective, and stabilizing effects for next-generation eye care products.

  • Dry eye score improvement – Proven efficacy in relieving symptoms
  • Cell protection – Reduces preservative-induced damage
  • Tear film stabilization – Prevents break-up and irritation
  • Moisturizing effect – Enhances ocular hydration
  • Contact lens compatibility – Suitable for hard and soft lenses

Additional Information

MPC-Polymer prevents efficiently cell damage by common preservatives.

Graph showing how MPC-Polymer prevents cell damage caused by common eye drop preservatives such as Benzalkonium Chloride (BAC) and Polyhexamethylenebiguanide (PHMB). Data illustrates reduced LDH release with 2% and 10% MPC-Polymer. Innovative solution by Nagase Pharma for safer ophthalmic formulations.

SIRC cells (10^4 cells/well) was incubated for 24 h. A solution with increasing BAC or PHMB concentration and MPC-Polymer (0, 2, 10 %) was added. The test was incubated for 5 min. The nutrient medium was collected and the absorbance of lactate dehydrogenase (LDH) was measured. The higher the concentration of LDH, the higher amount of damaged cells.

MPC-Polymer improves significantly the dry eye score

Bar chart showing that MPC-Polymer significantly improves the dry eye score compared to control, dry eye model, and saline treatment. Research by Nagase Pharma demonstrates the effectiveness of MPC-Polymer in enhancing eye hydration and reducing dry eye symptoms.
A dry eye model has been prepared (n=3). Forcibly open eyes for 3 hours. Each test solution has been instilled into the eyes every 30 min (in total 6x). After 3 hours the cornea has been dyed with methylene blue and the status of the dyed eye has been analyzed (0 = not dyed with dye; 2 = 1/4 to 1/2 are dyed).

Frequently Asked Questions about MPC-Polymer for Eye-Care

What is MPC Polymer and how does it work in eye drops?
MPC Polymer is a phosphoryl choline-based polymer that enhances hydration and stability in eye drops by preventing protein adhesion and improving tear film quality.

Why is MPC Polymer beneficial for dry eye treatment?
It stabilizes the tear film, prevents tear break-up, and improves dry eye scores, leading to greater comfort for patients with ocular dryness.

Does MPC Polymer protect against preservatives in formulations?
Yes, MPC Polymer reduces cell damage caused by preservatives, making eye drop solutions gentler on the ocular surface.

Can MPC Polymer be used with contact lenses?
Yes, MPC Polymer is suitable for both hard and soft contact lenses, improving lens comfort and reducing irritation.

Is MPC Polymer safe for long-term ophthalmic use?
MPC Polymer is highly biocompatible and widely used in commercial ophthalmic solutions, making it safe for long-term daily use.

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Pharmaceuticals

Volker Wagner
Sales Manager