MPC Polymer

Synthetic, water-soluble polymer with exceptional biocompatibility.
Optimized for IVD and assay reagent formulations in modern diagnostics.

Biocompatible Polymer for Reliable and Safe Diagnostic Applications

MPC Polymer (2-Methacryloyloxyethyl Phosphoryl Choline) is a fully synthetic, water-soluble polymer featuring a unique monomer composition that combines hydrophilic phosphoryl choline and methacrylic groups. These properties result in excellent biocompatibility and high hydrophilicity, making MPC Polymer ideal for use in IVD reagents and biochemical assay systems.

Its chemical synthesis ensures high purity and reproducibility with minimal biological risk and negligible lot-to-lot variation – essential in sensitive diagnostic environments.

NAGASE supplies MPC Polymer for IVD, immunoassays, and biomedical applications.

White Paper about MPC Polymer.

Immunoassay

Icon showing a 96-well microplate representing immunoassay applications of MPC Polymer.

Western Blotting

Icon of a Western blot band pattern, indicating use of MPC Polymer in Western blotting procedures.

Immunohisto-chemistry

Icon of an antibody and tissue structure, symbolizing immunohistochemistry applications for MPC Polymer.

Agglutination Assay

Icon showing aggregated particles representing agglutination assays supported by MPC Polymer.

Lateral Flow Tests

Icon of a rapid test cassette, representing lateral flow test applications using MPC Polymer.

Bead Based Assays

Icon of reagent-filled tube with assay beads, representing bead-based assay formats with MPC Polymer.

Applications

MPC Polymer is widely used in immunological and diagnostic assays due to its stability and biocompatibility.

  • Immunoassay development and optimization
  • Western Blotting for enhanced signal clarity
  • Immunohistochemistry applications
  • Agglutination assays requiring biocompatible reagents
  • Lateral flow tests with improved reagent performance
  • Bead-based assays for multiplex diagnostics

Features

MPC Polymer ensures reproducibility, safety, and high biocompatibility for advanced assay development.

  • Fully synthetic structure – Minimizes biological risk and contamination
  • High biocompatibility – Phosphoryl choline groups reduce non-specific interactions
  • Excellent hydrophilicity – Promotes stable dispersion in aqueous environments
  • Lot-to-lot consistency – Reliable performance across manufacturing batches
  • Versatile usage – Suitable for multiple diagnostic assay formats

Additional Information

Synthetic polymer (MPC-Polymer) Protein-based reagents
Lot-to-lot variation no yes
Danger of infection no yes
Stability high low
Reproducibility high high
Impurity no yes

 

MPC-Polymer effectively suppresses lot-to-lot variation.

Bar graph comparing absorption values of MPC Polymer and BSA across three lots (A, B, C), demonstrating consistent low absorption for MPC Polymer versus higher variability in BSA.

Blocking Effect

MPC-Polymer effectively suppresses non specific adsorption of protein on microplate or magnetic beads.

This experiment shows a 50 % better performance compared to the common material BSA.

Bar graph comparing non-specific signal levels (absorption at 450 nm) in ELISA tests using BSA, MPC Polymer, and no blocking agent. MPC Polymer shows the lowest background signal, indicating high blocking efficiency.
Figure 1: A MaxiSorp (Thermo Fisher Scientific) 8-well plate was blocked with 10-fold diluted MPC-Polymer (0,5 wt% final, diluted with PBS).

Protein Stabilization Effect

MPC-Polymer effectively stabilizes proteins on solid or liquid phase materials.

MPC-Polymer and its hydrated water surrounds proteins to optimize the hydrophobic balance, and suppresses denaturation, aggregation, and non-specific adsorption to inside wall of vessel.

This experiment shows a 50 % better performance compared to the common material BSA

Line graph showing relative stability over 20 days at 25 °C for samples treated with MPC Polymer, BSA, and no additive. MPC Polymer maintains the highest stability, outperforming BSA and untreated samples.
Figure 2: A anti-mouse IgG antibody was immobilzed on a MaxiSorp (Thermo Fisher Scientific) 8-well plate and afterwards blocked with 10-fold diluted MPC-Polymer (0,1 wt%).

Sensitizing Effect (Latex Agglutination Test)

MPC-Polymer effectively improves the sensitivity of latex agglutination tests.

Figure 3: A latex agglutination test detecting CRP (C-reactive protein) was carried out to evaluate the performance of MPC-Polymer. The test was performed using 7070 automated analyzer (Hitachi). MPC-Polymer was added to the sample diluent and to the latex particle suspension (1 wt% final concentration).

Sensitizing Effect (Lateral Flow Test)

MPC-Polymer significantly improves the sensitivity of lateral flowtests.

Figure 4: A lateral flow test detecting SARS-CoV-2 IgM and IgG antibody was carried out using a combination of two MPC-Polymers in the final concentration 0,75 wt% in the buffer solution.

Frequently Asked Questions about MPC-Polymer

What is MPC Polymer used for?
MPC Polymer is used as a high-performance additive in immunoassays, lateral flow tests, and other diagnostic applications due to its biocompatibility and water solubility.

Why is biocompatibility important in IVD reagents?
Biocompatibility ensures minimal interference or reaction with biological samples, which is crucial for the accuracy and reliability of diagnostic results.

What makes MPC Polymer different from other polymers?
MPC Polymer features phosphoryl choline groups that mimic biological membranes, reducing non-specific binding and increasing hydrophilicity.

Can MPC Polymer be used in sensitive applications like immunohistochemistry?
Yes, its chemical purity and consistency make it suitable for sensitive applications like immunohistochemistry and Western blotting.

Does MPC Polymer show batch-to-batch variability?
No, due to full chemical synthesis, MPC Polymer offers excellent lot-to-lot reproducibility.

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In Vitro Diagnostics

Aziza Aknin
Key Account Manager