Arcofeliz™ EN Series: Low-Endotoxin Enzymes

Arcofeliz™ EN Series includes low-endotoxin alginate lyase and low-endotoxin collagenase, both produced by microbial fermentation and purified with newly developed endotoxin removal materials (non-GMP).

These enzymes are designed for use as raw materials in medical and pharmaceutical R&D, where purity and biocompatibility are essential. Alginate lyase breaks down alginate and its salts into lower molecular weight and lower viscosity components, while collagenase hydrolyzes peptide bonds in collagen’s triple-helix structure, enabling efficient tissue remodeling or matrix degradation.

Produced via controlled microbial processes, Arcofeliz™ EN Series enzymes are free from animal-derived impurities, genetic modification, and pesticide residues, ensuring a safe and consistent supply for cell culture, regenerative medicine, and drug formulation applications.

NAGASE supplies Arcofeliz™ EN Series globally with full technical documentation, R&D support, and international logistics capabilities for medical and pharmaceutical researchers.

Arcofeliz™ EN Series provides high-purity alginate lyase and collagenase for biomedical and pharmaceutical research applications.

• Tissue engineering and regenerative medicine studies
• Cell culture requiring controlled enzymatic matrix degradation
• Drug formulation and biochemical processing R&D
• Biomedical coatings and material surface modification
• Pharmaceutical ingredient preparation under non-GMP research conditions

Arcofeliz™ EN Series enzymes offer precision, purity, and safety for advanced R&D use.

• Low-endotoxin grade – purified using proprietary endotoxin removal materials (non-GMP)
• Microbial fermentation origin – safe, consistent, and animal-free
• Alginate lyase – decomposes alginate into low-molecular-weight, low-viscosity fractions
• Collagenase – hydrolyzes peptide bonds in triple-helical collagen molecules
• Free from BSE risk, GMOs, and pesticide residues

What is Arcofeliz™ EN Series?
Arcofeliz™ EN Series includes low-endotoxin alginate lyase and collagenase enzymes purified for medical and pharmaceutical R&D applications.

What is the function of alginate lyase?
Alginate lyase decomposes alginate and its salts into lower molecular weight and viscosity, useful for biomaterial modification and tissue engineering.

What is the function of collagenase?
Collagenase is a protein-hydrolyzing enzyme that cleaves peptide bonds in collagen’s triple-helix, facilitating cell isolation and tissue remodeling.

How are these enzymes produced?
Both enzymes are produced via microbial fermentation, ensuring consistent quality and eliminating animal-derived contamination.

Are Arcofeliz™ EN Series enzymes suitable for GMP use?
No. These products are intended for non-GMP research applications such as material testing, formulation studies, and biomedical R&D.