CRP-S Latex Immuno Turbidimetric Assay

Rapid latex-based assay for inflammation marker CRP.
Enables reliable quantification of C-reactive protein levels in serum and plasma samples.

Latex Immunoturbidimetric Assay for Acute Inflammation and Infection Diagnostics

C-reactive protein (CRP) is a major acute-phase protein synthesized by hepatocytes in response to cytokine release following tissue injury or infection. Its serum concentration can rise up to 1,000-fold within hours and is widely used as a sensitive biomarker for inflammation.

CRP binds to phosphocholine on microbial surfaces and damaged cells, triggering the classical complement pathway as part of the innate immune response. This makes it a key indicator for systemic inflammation, infection, and sepsis.

The CRP-S latex immunoturbidimetric assay enables quantitative CRP measurement in human serum or plasma. Latex particles coated with polyclonal goat anti-human CRP antibodies agglutinate upon contact with CRP, with resulting turbidity proportional to the analyte concentration. Measurement is performed photometrically using a standard calibration curve.

NAGASE supplies CRP-S in bulk for OEM integration and clinical diagnostics. Functional principles align with findings by Sproston and Ashworth (Front. Immunol., 9:754, 2018).

Detection Limit

Correlation

Dilution Linearity

Detection limit graph showing CRP assay sensitivity with absorbance plotted against theoretical concentration. Dotted line indicates +2.6 SD threshold at 0.01 mg/dL.
Correlation chart comparing CRP values from NAGASE assay and competitor method. Linear regression shows strong correlation (r = 0.999, n = 100).
Linearity graph of CRP assay across dilution series for low and high concentration ranges, demonstrating consistent quantitative performance.

Applications

CRP-S is used for the quantitative determination of C-reactive protein in various diagnostic settings.

  • Detection of acute inflammation in clinical diagnostics
  • Infection monitoring in hospitals and outpatient care
  • Sepsis risk assessment based on CRP concentration
  • Supportive marker in autoimmune or chronic inflammatory diseases
  • CRP baseline measurement in preventive health screenings

Features

CRP-S offers fast and reproducible detection of CRP using latex-enhanced immunoturbidimetry.

  • Latex agglutination principle – Based on anti-human CRP antibodies for specific binding
  • High sensitivity – Detects CRP elevation even at low concentrations
  • Quantitative output – Photometric turbidity correlates with CRP concentration
  • Compatible with serum and plasma – Suitable for multiple sample types
  • OEM-ready – Supplied in bulk with global logistics and technical support

Benefits

  • Our wide measurement range (0.02 – 40 mg/dL) enables detection of high value samples without dilution.
  • Reliable test result due to minimized lot to lot variation.
CRP-S lot-to-lot variation graph showing consistent absorbance across 22 production batches over a concentration range of 0–40 mg/dL.
  • Compatible with almost all known analysers even by a range >40 mg/dL
  • Reagents are not affected by RF (Rheumatoid Factor)
Interference test showing CRP-S assay results remain stable across increasing rheumatoid factor (RF) concentrations up to 500 IU/mL.

Product Specification

  • Sensitivity
    Amount of change in absorbance for saline samples: 0.02 or less
  • Accuracy
    When control serum with known concentration is assayed, the result is whtin +/-10 % of the known concentration
  • Precision
    The CV of absorbance is 5 % or less when testing the same sample with 5 mg/dL of CRP for 20 times in the same run.
  • Assay Range
    0.02 – 40 mg/dL
  • Storage
    2-10 °C
  • Shelf Life
    1 year after production

Product Varieties

  • CRP-S Standard
  • Immunoquest ARC-S (lyophilized multi control for CRP, RF and ASO)
  • ASO reagent and standard
  • RF reagent and standard

Frequently Asked Questions about CRP-S Latex Immuno Turbidimetric Assay

What is CRP and why is it measured?
C-reactive protein (CRP) is an acute-phase protein produced by the liver during inflammation or infection. Measuring CRP helps assess the severity of inflammatory processes.

How does the CRP-S assay work?
The assay uses latex particles coated with anti-CRP antibodies. When mixed with serum or plasma containing CRP, these particles agglutinate, and the resulting turbidity is measured to determine CRP levels.

What are the typical applications of CRP testing?
CRP testing is used to monitor infections, detect inflammation, and assess the risk of sepsis or chronic inflammatory diseases such as arthritis.

Can this assay be used with both serum and plasma?
Yes, CRP-S is validated for use with both serum and plasma samples, offering flexibility for clinical workflows.

Does NAGASE offer this product in bulk for OEM use?
Yes, NAGASE supplies CRP-S in bulk quantities for OEM integration and clinical laboratories worldwide.

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In Vitro Diagnostics

Aziza Aknin
Key Account Manager